This theme addresses the production, separation, storage, and utilization of hydrogen isotopes (H, D, T) for applications in fusion and fission technologies, as well as in non-nuclear energy and industrial systems. Special emphasis is placed on advanced materials for isotope handling, structural components, membranes, coatings, cryogenic systems, and radiation-resistant environments, supported by digital modeling, simulation, and control tools to ensure safety, efficiency, and scalability under extreme operating conditions.